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chr19:45309039-45512650

203611 bp

More information

13 genes are contained within or overlap this genomic region:

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

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Genetic Variation

Variants contained within the region chr19:45309039-45512650.

14279 variant records to (corresponding to 13488 unique genomic positions) are contained within the region chr19:45309039-45512650.

Of these, the following were found to have genome-wide significance in a NIAGADS dataset or the NHGRI GWAS Catalog:

NIAGADS: Alzheimer's Disease

NIAGADS AD GWAS summary statistics datasets in which colocated variants have a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

Login in to select variants and add them to your basket.

Variant Allele p-Value Track Accession
A 0.000 ADGC 2011: Stages 1 and 2 NG00027
T 2.5e-575 IGAP 2013: Stage 1 NG00036
C 6.7e-536 IGAP 2013: Stage 1 NG00036
A 9.9e-523 IGAP 2013: Stage 1 NG00036
A 1.2e-522 IGAP 2013: Stage 1 NG00036
T 1.8e-520 IGAP 2013: Stage 1 NG00036
T 2.0e-486 IGAP 2013: Stage 1 NG00036
G 7.8e-482 IGAP 2013: Stage 1 NG00036
G 8.5e-475 IGAP 2013: Stage 1 NG00036
C 8.9e-469 IGAP 2013: Stage 1 NG00036
G 6.4e-466 IGAP 2013: Stage 1 NG00036
T 2.6e-464 IGAP 2013: Stage 1 NG00036
G 5.1e-464 IGAP 2013: Stage 1 NG00036
C 2.5e-462 IGAP 2013: Stage 1 NG00036
A 2.0e-454 IGAP 2013: Stage 1 NG00036
G 6.5e-442 IGAP 2013: Stage 1 NG00036
A 4.9e-440 IGAP 2013: Stage 1 NG00036
G 2.7e-434 IGAP 2013: Stage 1 NG00036
G 3.2e-434 IGAP 2013: Stage 1 NG00036
T 9.7e-434 IGAP 2013: Stage 1 NG00036
A 5.4e-432 IGAP 2013: Stage 1 NG00036
A 2.5e-427 IGAP 2013: Stage 1 NG00036
A 1.1e-421 IGAP 2013: Stage 1 NG00036
A 7.0e-405 IGAP 2013: Stage 1 NG00036
G 1.7e-396 IGAP 2013: Stage 1 NG00036
C 8.6e-390 IGAP 2013: Stage 1 NG00036
T 2.1e-373 IGAP 2013: Stage 1 NG00036
A 3.2e-354 IGAP 2013: Stage 1 NG00036
A 1.2e-342 IGAP 2013: Stage 1 NG00036
T 2.8e-326 IGAP 2013: Stage 1 NG00036
A 1.1e-266 ADGC 2011: Stage 1 NG00027
T 2.2e-206 ADGC 2011: Stage 1 NG00027
A 6.2e-184 ADGC 2011: Stage 1 NG00027
T 8.2e-178 ADGC 2011: Stage 1 NG00027
G 2.2e-167 IGAP 2013: Stage 1 NG00036
A 1.7e-134 IGAP 2013: Stage 1 NG00036
A 1.1e-128 ADGC 2011: Stage 1 NG00027
G 1.7e-128 IGAP 2013: Stage 1 NG00036
C 2.3e-127 IGAP 2013: Stage 1 NG00036
C 1.0e-126 IGAP 2013: Stage 1 NG00036
G 1.7e-126 IGAP 2013: Stage 1 NG00036
A 3.3e-125 IGAP 2013: Stage 1 NG00036
T 6.2e-125 IGAP 2013: Stage 1 NG00036
A 3.8e-121 ADGC 2011: Stage 2 NG00027
T 3.5e-115 IGAP 2013: Stage 1 NG00036
G 2.0e-114 IGAP 2013: Stage 1 NG00036
T 4.8e-114 IGAP 2013: Stage 1 NG00036
C 3.2e-112 IGAP 2013: Stage 1 NG00036
A 9.0e-109 IGAP 2013: Stage 1 NG00036
A 1.5e-108 IGAP 2013: Stage 1 NG00036
A 5.1e-104 IGAP 2013: Stage 1 NG00036
G 1.2e-101 IGAP 2013: Stage 1 NG00036
A 3.8e-101 IGAP 2013: Stage 1 NG00036
G 5.4e-97 IGAP 2013: Stage 1 NG00036
T 3.3e-96 ADGC Age of Onset LOAD NG00048
A 3.3e-96 IGAP 2013: Stage 1 NG00036
T 1.1e-93 ADGC Age of Onset LOAD NG00048
T 3.5e-93 ADGC Age of Onset LOAD NG00048
T 6.9e-89 IGAP 2013: Stage 1 NG00036
T 8.1e-89 ADGC Age of Onset LOAD NG00048
C 9.9e-89 IGAP 2013: Stage 1 NG00036
T 1.3e-88 IGAP 2013: Stage 1 NG00036
C 4.2e-87 IGAP 2013: Stage 1 NG00036
G 1.4e-86 IGAP 2013: Stage 1 NG00036
T 1.8e-85 IGAP 2013: Stage 1 NG00036
C 2.8e-85 IGAP 2013: Stage 1 NG00036
A 2.9e-85 IGAP 2013: Stage 1 NG00036
A 3.9e-85 IGAP 2013: Stage 1 NG00036
A 3.4e-84 ADGC Age of Onset LOAD NG00048
C 5.0e-84 ADGC Age of Onset LOAD NG00048
G 1.1e-83 IGAP 2013: Stage 1 NG00036
A 1.1e-82 IGAP 2013: Stage 1 NG00036
T 1.2e-82 IGAP 2013: Stage 1 NG00036
G 3.4e-82 IGAP 2013: Stage 1 NG00036
T 4.3e-82 IGAP 2013: Stage 1 NG00036
A 5.1e-82 ADGC Age of Onset LOAD NG00048
T 4.6e-81 ADGC Age of Onset LOAD NG00048
A 7.8e-81 IGAP 2013: Stage 1 NG00036
C 1.1e-80 IGAP 2013: Stage 1 NG00036
T 3.5e-79 IGAP 2013: Stage 1 NG00036
A 8.8e-79 ADGC Age of Onset LOAD NG00048
A 2.1e-76 IGAP 2013: Stage 1 NG00036
C 2.8e-76 IGAP 2013: Stage 1 NG00036
T 2.8e-76 IGAP 2013: Stage 1 NG00036
A 2.4e-75 ADGC Age of Onset LOAD NG00048
T 1.5e-74 ADGC Age of Onset LOAD NG00048
A 5.8e-74 ADGC 2011: Stages 1 and 2 NG00027
G 4.4e-73 IGAP 2013: Stage 1 NG00036
A 4.5e-73 ADGC Age of Onset LOAD NG00048
A 1.1e-72 ADGC Age of Onset LOAD NG00048
T 3.9e-72 IGAP 2013: Stage 1 NG00036
C 9.5e-71 ADGC Age of Onset LOAD NG00048
T 4.3e-70 ADGC Age of Onset LOAD NG00048
T 1.1e-69 ADGC Age of Onset LOAD NG00048
T 3.0e-69 IGAP 2013: Stage 1 NG00036
A 3.4e-69 ADGC Age of Onset LOAD NG00048
T 3.8e-69 IGAP 2013: Stage 1 NG00036
C 4.7e-69 IGAP 2013: Stage 1 NG00036
A 4.7e-69 IGAP 2013: Stage 1 NG00036
T 5.4e-69 IGAP 2013: Stage 1 NG00036
A 6.7e-69 ADGC Age of Onset LOAD NG00048
T 6.3e-68 IGAP 2013: Stage 1 NG00036
T 1.2e-67 IGAP 2013: Stage 1 NG00036
T 1.8e-67 IGAP 2013: Stage 1 NG00036
A 2.0e-67 IGAP 2013: Stage 1 NG00036
C 2.3e-67 IGAP 2013: Stage 1 NG00036
A 2.8e-67 ADGC Age of Onset LOAD NG00048
C 2.9e-67 ADGC 2011: Stages 1 and 2 NG00027
T 3.3e-67 IGAP 2013: Stage 1 NG00036
A 3.7e-67 ADGC Age of Onset LOAD NG00048
T 4.8e-67 IGAP 2013: Stage 1 NG00036
C 4.9e-67 IGAP 2013: Stage 1 NG00036
C 5.5e-67 IGAP 2013: Stage 1 NG00036
C 1.2e-66 IGAP 2013: Stage 1 NG00036
C 1.5e-65 IGAP 2013: Stage 1 NG00036
A 1.8e-65 IGAP 2013: Stage 1 NG00036
C 2.0e-65 IGAP 2013: Stage 1 NG00036
A 4.1e-65 IGAP 2013: Stage 1 NG00036
A 4.1e-65 IGAP 2013: Stage 1 NG00036
C 4.4e-65 IGAP 2013: Stage 1 NG00036
C 1.4e-64 IGAP 2013: Stage 1 NG00036
T 2.6e-64 IGAP 2013: Stage 1 NG00036
C 9.3e-64 IGAP 2013: Stage 1 NG00036
T 1.0e-63 ADGC Age of Onset LOAD NG00048
A 2.2e-63 IGAP 2013: Stage 1 NG00036
A 2.6e-63 IGAP 2013: Stage 1 NG00036
C 1.1e-62 IGAP 2013: Stage 1 NG00036
T 1.6e-62 ADGC Age of Onset LOAD NG00048
C 2.7e-62 IGAP 2013: Stage 1 NG00036
A 2.8e-62 IGAP 2013: Stage 1 NG00036
T 4.6e-62 IGAP 2013: Stage 1 NG00036
T 5.2e-62 ADGC Age of Onset LOAD NG00048
G 7.7e-61 IGAP 2013: Stage 1 NG00036
T 1.2e-60 IGAP 2013: Stage 1 NG00036
C 1.6e-60 ADGC Age of Onset LOAD NG00048
G 6.2e-60 IGAP 2013: Stage 1 NG00036
G 4.8e-59 IGAP 2013: Stage 1 NG00036
A 6.2e-59 ADGC Age of Onset LOAD NG00048
A 1.7e-58 IGAP 2013: Stage 1 NG00036
C 4.8e-58 IGAP 2013: Stage 1 NG00036
T 3.1e-56 ADGC Age of Onset LOAD NG00048
A 7.3e-56 ADGC Age of Onset LOAD NG00048
A 1.4e-54 ADGC 2011: Stage 1 NG00027
A 2.0e-53 ADGC Age of Onset LOAD NG00048
A 5.4e-53 IGAP 2013: Stage 1 NG00036
A 5.5e-53 IGAP 2013: Stage 1 NG00036
C 1.7e-52 IGAP 2013: Stage 1 NG00036
T 3.9e-52 IGAP 2013: Stage 1 NG00036
G 5.5e-52 IGAP 2013: Stage 1 NG00036
A 2.3e-50 IGAP 2013: Stage 1 NG00036
A 2.5e-50 ADGC 2011: Stage 1 NG00027
A 5.5e-48 ADGC Age of Onset LOAD NG00048
C 2.7e-47 ADGC 2011: Stages 1 and 2 NG00027
T 3.9e-47 ADGC 2011: Stages 1 and 2 NG00027
C 5.0e-47 ADGC 2011: Stage 1 NG00027
T 5.5e-47 ADGC African Americans 2013 NG00039
T 8.3e-47 IGAP 2013: Stage 1 NG00036
T 1.3e-45 IGAP 2013: Stage 1 NG00036
G 1.8e-45 IGAP 2013: Stage 1 NG00036
A 5.1e-45 ADGC 2011: Stage 1 NG00027
T 5.6e-45 ADGC 2011: Stage 1 NG00027
A 1.4e-44 IGAP 2013: Stage 1 NG00036
T 3.0e-44 ADGC 2011: Stage 1 NG00027
T 8.7e-44 ADGC 2011: Stages 1 and 2 NG00027
T 2.3e-40 IGAP 2013: Stage 1 NG00036
T 2.9e-40 IGAP 2013: Stage 1 NG00036
A 3.4e-40 IGAP 2013: Stage 1 NG00036
T 1.5e-39 IGAP 2013: Stage 1 NG00036
G 2.2e-39 IGAP 2013: Stage 1 NG00036
T 3.7e-36 IGAP 2013: Stage 1 NG00036
A 5.3e-36 IGAP 2013: Stage 1 NG00036
T 1.2e-34 IGAP 2013: Stage 1 NG00036
A 1.4e-33 IGAP 2013: Stage 1 NG00036
C 1.6e-33 ADGC 2011: Stage 1 NG00027
T 1.8e-33 ADGC 2011: Stage 1 NG00027
T 5.5e-33 IGAP 2013: Stage 1 NG00036
C 2.4e-32 ADGC 2011: Stage 1 NG00027
C 4.7e-32 IGAP 2013: Stage 1 NG00036
A 1.3e-31 IGAP 2013: Stage 1 NG00036
T 9.3e-31 IGAP 2013: Stage 1 NG00036
A 1.3e-30 IGAP 2013: Stage 1 NG00036
A 1.4e-30 ADGC Age of Onset LOAD NG00048
T 1.5e-30 IGAP 2013: Stage 1 NG00036
G 1.7e-30 IGAP 2013: Stage 1 NG00036
C 1.8e-30 IGAP 2013: Stage 1 NG00036
T 2.3e-30 IGAP 2013: Stage 1 NG00036
C 2.9e-30 IGAP 2013: Stage 1 NG00036
T 4.2e-30 ADGC 2011: Stage 1 NG00027
A 6.1e-30 ADGC Age of Onset LOAD NG00048
A 1.2e-29 IGAP 2013: Stage 1 NG00036
T 4.5e-29 IGAP 2013: Stage 1 NG00036
G 1.1e-28 IGAP 2013: Stage 1 NG00036
G 1.5e-28 IGAP 2013: Stage 1 NG00036
T 1.9e-28 ADGC 2011: Stages 1 and 2 NG00027
C 4.6e-28 IGAP 2013: Stage 1 NG00036
A 7.5e-28 ADGC 2011: Stage 1 NG00027
G 9.1e-28 IGAP 2013: Stage 1 NG00036
A 3.0e-27 ADGC African Americans 2013 NG00039
C 5.1e-27 IGAP 2013: Stage 1 NG00036
A 1.2e-26 ADGC 2011: Stage 2 NG00027
T 5.0e-26 ADGC Age of Onset LOAD NG00048
A 7.1e-26 ADGC Age of Onset LOAD NG00048
T 1.6e-24 IGAP 2013: Stage 1 NG00036
A 2.5e-24 ADGC Age of Onset LOAD NG00048
G 3.5e-24 IGAP 2013: Stage 1 NG00036
A 7.0e-24 ADGC 2011: Stages 1 and 2 NG00027
G 7.1e-24 IGAP 2013: Stage 1 NG00036
A 1.3e-23 ADGC African Americans 2013 NG00039
T 1.5e-23 IGAP 2013: Stage 1 NG00036
C 2.0e-23 ADGC 2011: Stage 2 NG00027
C 5.8e-23 IGAP 2013: Stage 1 NG00036
A 9.7e-23 IGAP 2013: Stage 1 NG00036
T 1.2e-22 IGAP 2013: Stage 1 NG00036
T 2.1e-22 ADGC African Americans 2013 NG00039
T 2.3e-22 ADGC African Americans 2013 NG00039
A 2.6e-22 ADGC African Americans 2013 NG00039
G 2.7e-22 IGAP 2013: Stage 1 NG00036
T 2.8e-22 ADGC African Americans 2013 NG00039
C 3.6e-22 ADGC Age of Onset LOAD NG00048
C 4.7e-22 ADGC African Americans 2013 NG00039
T 2.0e-21 IGAP 2013: Stage 1 NG00036
A 2.1e-21 ADGC Age of Onset LOAD NG00048
A 2.8e-21 IGAP 2013: Stage 1 NG00036
T 8.2e-21 ADGC 2011: Stage 1 NG00027
A 9.0e-21 ADGC African Americans 2013 NG00039
A 1.2e-20 ADGC Age of Onset LOAD NG00048
C 2.7e-20 IGAP 2013: Stage 1 NG00036
T 3.6e-20 ADGC African Americans 2013 NG00039
A 3.7e-20 ADGC African Americans 2013 NG00039
T 4.9e-20 ADGC African Americans 2013 NG00039
T 8.2e-20 ADGC African Americans 2013 NG00039
C 8.4e-20 ADGC Age of Onset LOAD NG00048
A 8.7e-20 ADGC African Americans 2013 NG00039
G 9.6e-20 IGAP 2013: Stage 1 NG00036
A 1.0e-19 IGAP 2013: Stage 1 NG00036
C 1.3e-19 IGAP 2013: Stage 1 NG00036
A 1.4e-19 ADGC Age of Onset LOAD NG00048
T 1.6e-19 ADGC African Americans 2013 NG00039
T 1.9e-19 ADGC African Americans 2013 NG00039
T 2.0e-19 ADGC Age of Onset LOAD NG00048
A 2.0e-19 ADGC Age of Onset LOAD NG00048
T 2.1e-19 ADGC Age of Onset LOAD NG00048
G 2.3e-19 IGAP 2013: Stage 1 NG00036
T 2.4e-19 ADGC Age of Onset LOAD NG00048
T 2.7e-19 ADGC African Americans 2013 NG00039
T 3.4e-19 ADGC 2011: Stages 1 and 2 NG00027
T 3.5e-19 ADGC African Americans 2013 NG00039
T 3.8e-19 ADGC Age of Onset LOAD NG00048
A 3.9e-19 ADGC 2011: Stages 1 and 2 NG00027
T 4.9e-19 ADGC 2011: Stages 1 and 2 NG00027
C 5.5e-19 ADGC Age of Onset LOAD NG00048
T 5.9e-19 ADGC Age of Onset LOAD NG00048
T 6.1e-19 IGAP 2013: Stage 1 NG00036
C 7.5e-19 IGAP 2013: Stage 1 NG00036
T 7.8e-19 ADGC Age of Onset LOAD NG00048
A 8.2e-19 IGAP 2013: Stage 1 NG00036
C 1.0e-18 IGAP 2013: Stage 1 NG00036
G 1.0e-18 IGAP 2013: Stage 1 NG00036
A 1.1e-18 IGAP 2013: Stage 1 NG00036
G 1.3e-18 IGAP 2013: Stage 1 NG00036
A 1.3e-18 IGAP 2013: Stage 1 NG00036
A 1.6e-18 ADGC Age of Onset LOAD NG00048
T 2.1e-18 IGAP 2013: Stage 1 NG00036
A 2.1e-18 IGAP 2013: Stage 1 NG00036
A 2.1e-18 IGAP 2013: Stage 1 NG00036
G 2.2e-18 IGAP 2013: Stage 1 NG00036
A 2.3e-18 ADGC African Americans 2013 NG00039
A 2.4e-18 IGAP 2013: Stage 1 NG00036
C 2.4e-18 IGAP 2013: Stage 1 NG00036
A 2.5e-18 IGAP 2013: Stage 1 NG00036
T 2.5e-18 IGAP 2013: Stage 1 NG00036
G 2.6e-18 IGAP 2013: Stage 1 NG00036
G 2.6e-18 IGAP 2013: Stage 1 NG00036
T 3.0e-18 IGAP 2013: Stage 1 NG00036
A 3.3e-18 IGAP 2013: Stage 1 NG00036
C 4.3e-18 IGAP 2013: Stage 1 NG00036
A 5.1e-18 IGAP 2013: Stage 1 NG00036
T 5.1e-18 IGAP 2013: Stage 1 NG00036
A 5.8e-18 IGAP 2013: Stage 1 NG00036
T 5.9e-18 IGAP 2013: Stage 1 NG00036
C 5.9e-18 IGAP 2013: Stage 1 NG00036
A 6.0e-18 ADGC Age of Onset LOAD NG00048
T 6.0e-18 ADGC Age of Onset LOAD NG00048
C 6.6e-18 IGAP 2013: Stage 1 NG00036
A 8.2e-18 IGAP 2013: Stage 1 NG00036
A 8.8e-18 IGAP 2013: Stage 1 NG00036
A 9.5e-18 IGAP 2013: Stage 1 NG00036
G 9.6e-18 IGAP 2013: Stage 1 NG00036
A 1.1e-17 IGAP 2013: Stage 1 NG00036
T 1.2e-17 ADGC African Americans 2013 NG00039
A 1.3e-17 ADGC 2011: Stages 1 and 2 NG00027
G 1.4e-17 IGAP 2013: Stage 1 NG00036
A 2.0e-17 ADGC Age of Onset LOAD NG00048
C 2.0e-17 IGAP 2013: Stage 1 NG00036
T 2.1e-17 IGAP 2013: Stage 1 NG00036
T 2.5e-17 IGAP 2013: Stage 1 NG00036
T 3.0e-17 IGAP 2013: Stage 1 NG00036
C 3.2e-17 ADGC Age of Onset LOAD NG00048
T 6.7e-17 ADGC Age of Onset LOAD NG00048
T 7.6e-17 IGAP 2013: Stage 1 NG00036
T 9.6e-17 IGAP 2013: Stage 1 NG00036
A 1.3e-16 ADGC Age of Onset LOAD NG00048
A 1.6e-16 ADGC African Americans 2013 NG00039
T 2.0e-16 ADGC 2011: Stages 1 and 2 NG00027
T 2.3e-16 IGAP 2013: Stage 1 NG00036
T 2.5e-16 ADGC 2011: Stage 2 NG00027
A 2.8e-16 IGAP 2013: Stage 1 NG00036
C 2.9e-16 ADGC 2011: Stage 2 NG00027
G 2.9e-16 IGAP 2013: Stage 1 NG00036
T 3.0e-16 ADGC 2011: Stage 2 NG00027
G 3.3e-16 IGAP 2013: Stage 1 NG00036
G 3.4e-16 IGAP 2013: Stage 1 NG00036
A 3.5e-16 IGAP 2013: Stage 1 NG00036
C 3.5e-16 IGAP 2013: Stage 1 NG00036
A 4.1e-16 ADGC African Americans 2013 NG00039
A 4.7e-16 IGAP 2013: Stage 1 NG00036
T 5.0e-16 IGAP 2013: Stage 1 NG00036
A 6.3e-16 ADGC 2011: Stage 1 NG00027
T 7.1e-16 ADGC Age of Onset LOAD NG00048
A 7.4e-16 IGAP 2013: Stage 1 NG00036
C 8.2e-16 IGAP 2013: Stage 1 NG00036
C 9.8e-16 IGAP 2013: Stage 1 NG00036
A 9.9e-16 ADGC 2011: Stages 1 and 2 NG00027
A 1.2e-15 ADGC African Americans 2013 NG00039
C 1.4e-15 IGAP 2013: Stage 1 NG00036
A 1.7e-15 ADGC Age of Onset LOAD NG00048
G 1.8e-15 IGAP 2013: Stage 1 NG00036
A 1.8e-15 ADGC African Americans 2013 NG00039
T 2.1e-15 ADGC Age of Onset LOAD NG00048
C 2.2e-15 ADGC Age of Onset LOAD NG00048
G 2.3e-15 IGAP 2013: Stage 1 NG00036
A 3.0e-15 IGAP 2013: Stage 1 NG00036
C 3.4e-15 ADGC African Americans 2013 NG00039
T 4.5e-15 IGAP 2013: Stage 1 NG00036
A 5.2e-15 IGAP 2013: Stage 1 NG00036
G 5.4e-15 IGAP 2013: Stage 1 NG00036
C 6.0e-15 IGAP 2013: Stage 1 NG00036
A 6.7e-15 IGAP 2013: Stage 1 NG00036
A 6.9e-15 ADGC Age of Onset LOAD NG00048
T 8.5e-15 ADGC 2011: Stages 1 and 2 NG00027
A 9.9e-15 IGAP 2013: Stage 1 NG00036
A 1.1e-14 ADGC 2011: Stages 1 and 2 NG00027
A 1.1e-14 ADGC Age of Onset LOAD NG00048
T 1.1e-14 ADGC African Americans 2013 NG00039
T 1.2e-14 ADGC African Americans 2013 NG00039
A 1.6e-14 IGAP 2013: Stage 1 NG00036
A 1.8e-14 ADGC 2011: Stage 1 NG00027
A 1.9e-14 ADGC 2011: Stage 1 NG00027
C 2.1e-14 IGAP 2013: Stage 1 NG00036
C 2.4e-14 ADGC Age of Onset LOAD NG00048
G 2.5e-14 IGAP 2013: Stage 1 NG00036
T 2.6e-14 IGAP 2013: Stage 1 NG00036
A 3.4e-14 ADGC 2011: Stages 1 and 2 NG00027
T 3.5e-14 ADGC 2011: Stage 1 NG00027
T 4.5e-14 ADGC 2011: Stage 1 NG00027
T 5.4e-14 IGAP 2013: Stage 1 NG00036
A 5.5e-14 ADGC 2011: Stages 1 and 2 NG00027
A 5.8e-14 ADGC African Americans 2013 NG00039
T 6.5e-14 ADGC 2011: Stages 1 and 2 NG00027
C 7.3e-14 IGAP 2013: Stage 1 NG00036
T 1.1e-13 ADGC Age of Onset LOAD NG00048
C 1.2e-13 IGAP 2013: Stage 1 NG00036
A 1.3e-13 IGAP 2013: Stage 1 NG00036
T 1.5e-13 IGAP 2013: Stage 1 NG00036
G 1.9e-13 IGAP 2013: Stage 1 NG00036
A 2.0e-13 ADGC Age of Onset LOAD NG00048
T 2.2e-13 IGAP 2013: Stage 1 NG00036
G 2.3e-13 IGAP 2013: Stage 1 NG00036
A 2.8e-13 ADGC African Americans 2013 NG00039
C 3.4e-13 IGAP 2013: Stage 1 NG00036
T 3.4e-13 ADGC African Americans 2013 NG00039
A 4.8e-13 IGAP 2013: Stage 1 NG00036
A 7.4e-13 ADGC 2011: Stage 1 NG00027
A 8.8e-13 IGAP 2013: Stage 1 NG00036
C 1.1e-12 IGAP 2013: Stage 1 NG00036
G 1.5e-12 IGAP 2013: Stage 1 NG00036
C 1.6e-12 IGAP 2013: Stage 1 NG00036
A 1.8e-12 IGAP 2013: Stage 1 NG00036
T 2.0e-12 IGAP 2013: Stage 1 NG00036
G 2.3e-12 IGAP 2013: Stage 1 NG00036
G 2.8e-12 IGAP 2013: Stage 1 NG00036
C 2.8e-12 IGAP 2013: Stage 1 NG00036
G 3.0e-12 IGAP 2013: Stage 1 NG00036
A 3.1e-12 ADGC African Americans 2013 NG00039
A 3.2e-12 ADGC African Americans 2013 NG00039
G 3.6e-12 IGAP 2013: Stage 1 NG00036
C 4.4e-12 IGAP 2013: Stage 1 NG00036
A 4.6e-12 ADGC African Americans 2013 NG00039
C 4.6e-12 IGAP 2013: Stage 1 NG00036
C 4.8e-12 IGAP 2013: Stage 1 NG00036
T 5.4e-12 IGAP 2013: Stage 1 NG00036
T 5.5e-12 ADGC African Americans 2013 NG00039
T 6.1e-12 ADGC African Americans 2013 NG00039
A 6.8e-12 IGAP 2013: Stage 1 NG00036
T 6.8e-12 ADGC African Americans 2013 NG00039
C 7.3e-12 ADGC African Americans 2013 NG00039
A 8.2e-12 IGAP 2013: Stage 1 NG00036
A 8.8e-12 ADGC 2011: Stage 1 NG00027
T 9.3e-12 IGAP 2013: Stage 1 NG00036
A 9.6e-12 ADGC African Americans 2013 NG00039
A 1.0e-11 ADGC 2011: Stage 2 NG00027
T 1.0e-11 ADGC 2011: Stage 1 NG00027
A 1.2e-11 ADGC Age of Onset LOAD NG00048
T 1.3e-11 IGAP 2013: Stage 1 NG00036
C 1.3e-11 IGAP 2013: Stage 1 NG00036
C 1.4e-11 ADGC African Americans 2013 NG00039
G 1.4e-11 IGAP 2013: Stage 1 NG00036
C 1.5e-11 IGAP 2013: Stage 1 NG00036
T 1.5e-11 IGAP 2013: Stage 1 NG00036
A 1.5e-11 ADGC 2011: Adjusted Stage 1 NG00027
T 1.5e-11 IGAP 2013: Stage 1 NG00036
T 1.6e-11 IGAP 2013: Stage 1 NG00036
G 1.6e-11 IGAP 2013: Stage 1 NG00036
T 1.8e-11 IGAP 2013: Stage 1 NG00036
T 1.8e-11 IGAP 2013: Stage 1 NG00036
G 2.2e-11 IGAP 2013: Stage 1 NG00036
A 2.2e-11 IGAP 2013: Stage 1 NG00036
G 2.3e-11 IGAP 2013: Stage 1 NG00036
A 2.3e-11 IGAP 2013: Stage 1 NG00036
A 2.3e-11 IGAP 2013: Stage 1 NG00036
T 2.4e-11 ADGC African Americans 2013 NG00039
G 2.6e-11 IGAP 2013: Stage 1 NG00036
T 2.9e-11 ADGC 2011: Stage 1 NG00027
T 3.1e-11 IGAP 2013: Stage 1 NG00036
T 3.4e-11 IGAP 2013: Stage 1 NG00036
T 3.4e-11 IGAP 2013: Stage 1 NG00036
T 3.6e-11 IGAP 2013: Stage 1 NG00036
A 3.6e-11 IGAP 2013: Stage 1 NG00036
G 3.8e-11 IGAP 2013: Stage 1 NG00036
C 3.9e-11 IGAP 2013: Stage 1 NG00036
G 4.0e-11 IGAP 2013: Stage 1 NG00036
G 4.0e-11 IGAP 2013: Stage 1 NG00036
C 4.0e-11 IGAP 2013: Stage 1 NG00036
G 4.1e-11 IGAP 2013: Stage 1 NG00036
A 4.1e-11 IGAP 2013: Stage 1 NG00036
A 4.3e-11 IGAP 2013: Stage 1 NG00036
A 4.3e-11 IGAP 2013: Stage 1 NG00036
C 4.3e-11 IGAP 2013: Stage 1 NG00036
G 4.3e-11 IGAP 2013: Stage 1 NG00036
T 4.3e-11 IGAP 2013: Stage 1 NG00036
C 4.4e-11 IGAP 2013: Stage 1 NG00036
C 4.6e-11 IGAP 2013: Stage 1 NG00036
A 4.9e-11 ADGC African Americans 2013 NG00039
A 4.9e-11 IGAP 2013: Stage 1 NG00036
C 5.1e-11 IGAP 2013: Stage 1 NG00036
T 5.4e-11 IGAP 2013: Stage 1 NG00036
C 5.5e-11 IGAP 2013: Stage 1 NG00036
A 5.6e-11 IGAP 2013: Stage 1 NG00036
A 5.7e-11 IGAP 2013: Stage 1 NG00036
A 6.2e-11 ADGC 2011: Stages 1 and 2 NG00027
A 6.5e-11 ADGC African Americans 2013 NG00039
A 6.8e-11 IGAP 2013: Stage 1 NG00036
C 7.1e-11 IGAP 2013: Stage 1 NG00036
G 9.2e-11 IGAP 2013: Stage 1 NG00036
T 9.5e-11 ADGC African Americans 2013 NG00039
T 9.9e-11 IGAP 2013: Stage 1 NG00036
C 1.1e-10 IGAP 2013: Stage 1 NG00036
A 1.2e-10 ADGC African Americans 2013 NG00039
T 1.3e-10 ADGC 2011: Stages 1 and 2 NG00027
A 1.3e-10 IGAP 2013: Stage 1 NG00036
A 1.4e-10 IGAP 2013: Stage 1 NG00036
C 1.5e-10 IGAP 2013: Stage 1 NG00036
G 1.7e-10 IGAP 2013: Stage 1 NG00036
T 1.7e-10 IGAP 2013: Stage 1 NG00036
T 1.8e-10 IGAP 2013: Stage 1 NG00036
T 1.8e-10 IGAP 2013: Stage 1 NG00036
A 1.8e-10 ADGC Age of Onset LOAD NG00048
A 1.8e-10 IGAP 2013: Stage 1 NG00036
C 2.2e-10 IGAP 2013: Stage 1 NG00036
C 2.2e-10 IGAP 2013: Stage 1 NG00036
T 2.4e-10 ADGC Age of Onset LOAD NG00048
A 2.5e-10 IGAP 2013: Stage 1 NG00036
C 2.6e-10 IGAP 2013: Stage 1 NG00036
G 2.7e-10 IGAP 2013: Stage 1 NG00036
C 2.8e-10 IGAP 2013: Stage 1 NG00036
A 2.8e-10 IGAP 2013: Stage 1 NG00036
A 3.0e-10 ADGC Age of Onset LOAD NG00048
T 3.0e-10 ADGC African Americans 2013 NG00039
C 3.0e-10 IGAP 2013: Stage 1 NG00036
A 3.1e-10 ADGC African Americans 2013 NG00039
A 3.4e-10 IGAP 2013: Stage 1 NG00036
T 3.6e-10 IGAP 2013: Stage 1 NG00036
T 3.7e-10 ADGC Age of Onset LOAD NG00048
C 3.8e-10 IGAP 2013: Stage 1 NG00036
C 3.8e-10 IGAP 2013: Stage 1 NG00036
T 3.8e-10 IGAP 2013: Stage 1 NG00036
T 3.9e-10 ADGC African Americans 2013 NG00039
A 4.2e-10 IGAP 2013: Stage 1 NG00036
A 4.4e-10 IGAP 2013: Stage 1 NG00036
C 4.8e-10 IGAP 2013: Stage 1 NG00036
C 4.9e-10 IGAP 2013: Stage 1 NG00036
A 5.5e-10 ADGC 2011: Adjusted Stage 1 NG00027
T 5.5e-10 ADGC African Americans 2013 NG00039
A 5.6e-10 IGAP 2013: Stage 1 NG00036
T 5.7e-10 IGAP 2013: Stage 1 NG00036
C 5.7e-10 IGAP 2013: Stage 1 NG00036
T 6.4e-10 IGAP 2013: Stage 1 NG00036
A 6.6e-10 ADGC 2011: Adjusted Stages 1 and 2 NG00027
A 6.7e-10 ADGC 2011: Stage 1 NG00027
T 7.7e-10 ADGC 2011: Stage 1 NG00027
T 8.3e-10 ADGC Age of Onset LOAD NG00048
A 8.5e-10 ADGC 2011: Stages 1 and 2 NG00027
A 8.6e-10 ADGC Age of Onset LOAD NG00048
A 9.5e-10 IGAP 2013: Stage 1 NG00036
A 1.0e-9 ADGC 2011: Stage 1 NG00027
T 1.1e-9 ADGC African Americans 2013 NG00039
T 1.1e-9 ADGC 2011: Stage 2 NG00027
T 1.1e-9 IGAP 2013: Stage 1 NG00036
A 1.2e-9 IGAP 2013: Stage 1 NG00036
C 1.3e-9 IGAP 2013: Stage 1 NG00036
A 1.7e-9 ADGC Age of Onset LOAD NG00048
T 1.8e-9 ADGC African Americans 2013 NG00039
A 2.4e-9 ADGC 2011: Adjusted Stage 1 NG00027
C 2.6e-9 IGAP 2013: Stage 1 NG00036
A 2.6e-9 IGAP 2013: Stage 1 NG00036
G 2.7e-9 IGAP 2013: Stage 1 NG00036
A 3.6e-9 ADGC African Americans 2013 NG00039
A 3.7e-9 ADGC African Americans 2013 NG00039
G 5.0e-9 IGAP 2013: Stage 1 NG00036
G 5.0e-9 IGAP 2013: Stage 1 NG00036
T 5.1e-9 ADGC African Americans 2013 NG00039
T 5.2e-9 ADGC African Americans 2013 NG00039
T 5.6e-9 ADGC Age of Onset LOAD NG00048
T 5.7e-9 IGAP 2013: Stage 1 NG00036
T 6.8e-9 ADGC African Americans 2013 NG00039
A 7.0e-9 ADGC African Americans 2013 NG00039
A 7.5e-9 IGAP 2013: Stage 1 NG00036
T 7.8e-9 IGAP 2013: Stage 1 NG00036
T 8.2e-9 IGAP 2013: Stage 1 NG00036
T 8.6e-9 ADGC 2011: Stages 1 and 2 NG00027
G 9.1e-9 IGAP 2013: Stage 1 NG00036
T 9.1e-9 IGAP 2013: Stage 1 NG00036
A 1.0e-8 IGAP 2013: Stage 1 NG00036
A 1.0e-8 ADGC Age of Onset LOAD NG00048
T 1.1e-8 IGAP 2013: Stage 1 NG00036
T 1.1e-8 IGAP 2013: Stage 1 NG00036
A 1.2e-8 ADGC African Americans 2013 NG00039
A 1.3e-8 ADGC African Americans 2013 NG00039
A 1.3e-8 IGAP 2013: Stage 1 NG00036
T 1.3e-8 ADGC African Americans 2013 NG00039
T 1.4e-8 IGAP 2013: Stage 1 NG00036
G 1.4e-8 IGAP 2013: Stage 1 NG00036
T 1.4e-8 IGAP 2013: Stage 1 NG00036
T 1.5e-8 ADGC 2011: Adjusted Stage 1 NG00027
T 1.5e-8 ADGC African Americans 2013 NG00039
T 1.5e-8 ADGC Age of Onset LOAD NG00048
C 1.5e-8 IGAP 2013: Stage 1 NG00036
T 1.6e-8 ADGC Age of Onset LOAD NG00048
A 1.7e-8 ADGC African Americans 2013 NG00039
T 1.7e-8 ADGC 2011: Stages 1 and 2 NG00027
T 1.7e-8 ADGC African Americans 2013 NG00039
A 1.9e-8 IGAP 2013: Stage 1 NG00036
A 2.0e-8 ADGC African Americans 2013 NG00039
T 2.1e-8 ADGC African Americans 2013 NG00039
A 2.2e-8 ADGC African Americans 2013 NG00039
T 2.4e-8 ADGC African Americans 2013 NG00039
A 2.4e-8 ADGC African Americans 2013 NG00039
A 2.5e-8 IGAP 2013: Stage 1 NG00036
T 2.5e-8 ADGC African Americans 2013 NG00039
T 2.7e-8 IGAP 2013: Stage 1 NG00036
T 2.8e-8 IGAP 2013: Stage 1 NG00036
A 2.9e-8 ADGC 2011: Stage 1 NG00027
T 3.1e-8 ADGC African Americans 2013 NG00039
A 3.1e-8 ADGC African Americans 2013 NG00039
T 3.4e-8 IGAP 2013: Stage 1 NG00036
T 3.5e-8 IGAP 2013: Stage 1 NG00036
T 4.0e-8 ADGC Age of Onset LOAD NG00048
G 4.2e-8 IGAP 2013: Stage 1 NG00036
T 4.3e-8 ADGC Age of Onset LOAD NG00048
A 4.6e-8 ADGC Age of Onset LOAD NG00048
T 4.6e-8 ADGC African Americans 2013 NG00039
A 4.7e-8 ADGC Age of Onset LOAD NG00048
A 4.9e-8 ADGC African Americans 2013 NG00039
C 5.0e-8 ADGC Age of Onset LOAD NG00048

NHGRI: Alzheimer's Disease

Alzheimer's Disease-related annotations for the dbSNP refSNPs contained within this region in the NHGRI GWAS Catalog.

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Variant Allele Frequency p-Value Odds Ratio/Beta Trait EFO Study Design Study
G 0.140 1.0e-295 2.53 Alzheimers disease EFO_0000249 6,505 European ancestry cases, 13,532 European ancestry controls Genome-wide analysis of genetic loci associated with Alzheimer disease. PMID: 20460622
? 0.150 2.0e-157 2.53 Alzheimers disease EFO_0000249 2,023 European ancestry cases, 2,340 European ancestry controls Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. PMID: 19734902
? N/A 8.0e-149 3.45 Alzheimers disease EFO_0000249 509 European ancestry cases, 753 European ancestry controls, 2,218 cases, 2,583 controls Genome-wide association study of Alzheimer's disease. PMID: 22832961
G N/A 9.0e-116 4.48 Alzheimers disease EFO_0000249 N/A Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. PMID: 24755620
? N/A 8.0e-89 1.69 Alzheimers disease EFO_0000249 4,982 European ancestry cases, 7,961 European ancestry controls, 2,190 cases, 3,374 controls The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. PMID: 21627779
T 0.288 2.0e-62 1.6136 Alzheimer's disease neuropathologic change EFO_0006801 N/A Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PMID: 25188341
? 0.260 9.0e-52 2.3 Alzheimers disease EFO_0000249 N/A Genome-wide association study of Alzheimer's disease with psychotic symptoms. PMID: 22005930
? N/A 2.0e-44 N/A Alzheimers disease EFO_0000249 418 European ancestry cases, 249 European ancestry controls Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. PMID: 17998437
? N/A 1.0e-40 N/A Alzheimers disease EFO_0000249 N/A Examination of the current top candidate genes for AD in a genome-wide association study. PMID: 19125160
? N/A 1.0e-39 4.01 Alzheimers disease EFO_0000249 N/A A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. PMID: 17474819
? N/A 1.0e-39 N/A Alzheimers disease EFO_0000249 N/A Sorl1 as an Alzheimer's disease predisposition gene? PMID: 17975299
G 0.290 5.0e-39 2.09 Alzheimers disease EFO_0000249 1,224 East Asian ancestry cases, 2,114 East Asian ancestry controls, 11,840 European ancestry cases, 10,931 European ancestry controls SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PMID: 23565137
T 0.286 3.0e-38 1.501 Alzheimer's disease neuropathologic change EFO_0006801 N/A Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PMID: 25188341
G 0.200 5.0e-36 2.94 Alzheimers disease EFO_0000249 1,338 cases, 2,003 controls Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities. PMID: 20885792
A N/A 3.0e-24 10.157 Alzheimers disease EFO_0000249 N/A Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. PMID: 26830138
A N/A 2.0e-18 0.091 Alzheimers disease EFO_0000249 N/A GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. PMID: 23562540
? 0.442 4.0e-17 0.4 Alzheimers disease EFO_0000249 515 individuals SUCLG2 identified as both a determinator of CSF Au00df1-42-levels and an attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
? 0.900 2.0e-16 N/A Alzheimers disease EFO_0000249 3,978 European ancestry cases, 3,297 European ancestry controls Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. PMID: 19734903
A N/A 2.0e-16 N/A Alzheimers disease