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Genomics in neurological disorders.

TitleGenomics in neurological disorders.
Publication TypeJournal Article
Year of Publication2014
AuthorsHan, G, Sun, J, Wang, J, Bai, Z, Song, F, Lei, H
JournalGenomics Proteomics Bioinformatics
Volume12
Issue4
Pagination156-63
Date Published2014 Aug
ISSN2210-3244
KeywordsGenomics, Humans, Nervous System Diseases
Abstract

Neurological disorders comprise a variety of complex diseases in the central nervous system, which can be roughly classified as neurodegenerative diseases and psychiatric disorders. The basic and translational research of neurological disorders has been hindered by the difficulty in accessing the pathological center (i.e., the brain) in live patients. The rapid advancement of sequencing and array technologies has made it possible to investigate the disease mechanism and biomarkers from a systems perspective. In this review, recent progresses in the discovery of novel risk genes, treatment targets and peripheral biomarkers employing genomic technologies will be discussed. Our major focus will be on two of the most heavily investigated neurological disorders, namely Alzheimer's disease and autism spectrum disorder.

DOI10.1016/j.gpb.2014.07.002
Alternate JournalGenomics Proteomics Bioinformatics
PubMed ID25108264
PubMed Central IDPMC4411357