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Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

TitleSubcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
Publication TypeJournal Article
Year of Publication2022
AuthorsDima D, Modabbernia A, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI et al.
Corporate AuthorsKarolinska Schizophrenia Project(KaSP)
JournalHum Brain Mapp
Volume43
Issue1
Pagination452-469
Date Published2022 Jan
ISSN1097-0193
Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

DOI10.1002/hbm.25320
Pubmed Linkhttps://www.ncbi.nlm.nih.gov/pubmed/33570244?dopt=Abstract
page_expoInternal
Alternate JournalHum Brain Mapp
PubMed ID33570244
PubMed Central IDPMC8675429
Grant List / / Brain Injury Fund Research Grant Program /
R01 MH104284 / MH / NIMH NIH HHS / United States
R01 MH113619 / MH / NIMH NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
/ / South London and Maudsley NHS Foundation Trust /
R01MH117014 / MH / NIMH NIH HHS / United States
/ / Nederlandse Organisatie voor Wetenschappelijk Onderzoek /
RO1HD050735 / / US National Institute of Child Health and Human Development /
PI020499 / / Instituto de Salud Carlos III /
/ / Universiteit Utrecht /
R01 AG058854 / AG / NIA NIH HHS / United States
/ / German Centre for Cardiovascular Research /
/ / Siemens Healthineers /
2019107 / / South Eastern Norway Regional Health Authority /
/ / King's College London /
R01 AG019771 / AG / NIA NIH HHS / United States
UL1 RR025761 / RR / NCRR NIH HHS / United States
/ / NWO Brain & Cognition Excellence Program /
NCT0235832 / / Fundación Instituto de Investigación Marqués de Valdecilla /
MH104284 / MH / NIMH NIH HHS / United States
223273 / / the Research Council /
/ / Netherlands Organization for Scientific Research /
P30 AG10133 / / U.S. National Institutes of Health /
10-000-1001 / / Geestkracht Programme of the Dutch Health Research Council /
P30 AG010133 / AG / NIA NIH HHS / United States
/ / Netherlands Organization for Health Research and Development /
/ / Vici Innovation Program /
/ / National Institute for Health Research /
/ / Australian National Health and Medical Research Council /
/ / Eunice Kennedy Shriver National Institute of Child Health & Human Development /
R01 MH117014 / MH / NIMH NIH HHS / United States
MH116147 / MH / NIMH NIH HHS / United States
/ / FP7 Ideas: European Research Council /
U01 AG068057 / AG / NIA NIH HHS / United States
/ / Epilepsy Therapy Project, Fight Against Childhood Epilepsy and Seizures /
/ / Parents Against Childhood Epilepsy /
/ / Southern and Eastern Norway Regional Health Authority /
/ / Indiana State Department of Health Spinal Cord /
R01 MH116147 / MH / NIMH NIH HHS / United States
PI14/00918 / / Instituto de Salud Carlos III /
/ / Karolinska Institutet /
/ / Hersenstichting Nederland /
R01MH113619 / MH / NIMH NIH HHS / United States
R01 HD050735 / HD / NICHD NIH HHS / United States
/ / Knut and Alice Wallenberg Foundation /
602450 / / European Community's Seventh Framework Programme /
API07/011 / / Fundación Instituto de Investigación Marqués de Valdecilla /
UL1 TR000153 / TR / NCATS NIH HHS / United States
/ / DZHK /
G0500092 / MRC_ / Medical Research Council / United Kingdom
U24 RR021992 / RR / NCRR NIH HHS / United States
R01MH042191 / MH / NIMH NIH HHS / United States
R01 MH042191 / MH / NIMH NIH HHS / United States
R01 AG060610 / AG / NIA NIH HHS / United States
/ NH / NIH HHS / United States
R01 CA101318 / CA / NCI NIH HHS / United States
PI060507 / / Instituto de Salud Carlos III /
R01 MH119219 / MH / NIMH NIH HHS / United States
PI050427 / / Instituto de Salud Carlos III /
/ / European Community's Horizon 2020 Programme /
R01 AG19771 / / U.S. National Institutes of Health /
/ / Swedish Research Council /
/ / Biomedical Research Centre /
/ / Stockholm County Council /
/ / Epilepsy Foundation /
/ / American Epilepsy Society /
UL1 TR000153 / DA / NIDA NIH HHS / United States
U24 RR025736 / RR / NCRR NIH HHS / United States
1 U24 RR025736-01 / DA / NIDA NIH HHS / United States
2017-112 / / South Eastern Norway Regional Health Authority /
1 U24 RR021992 / DA / NIDA NIH HHS / United States
NCT02534363 / / Fundación Instituto de Investigación Marqués de Valdecilla /
PI14/00639 / / Instituto de Salud Carlos III /
R01 MH090553 / MH / NIMH NIH HHS / United States
/ / University of Queensland /
RC2 DA029475 / DA / NIDA NIH HHS / United States

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