Title | Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS |
Corporate Authors | MEGASTROKE project of the International Stroke Genetics Consortium |
Journal | Neurology |
Volume | 92 |
Issue | 9 |
Pagination | e944-e950 |
Date Published | 2019 02 26 |
ISSN | 1526-632X |
Keywords | Brain Ischemia, Calcium, Humans, Intracranial Embolism, Magnesium, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Stroke |
Abstract | OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.
METHODS: Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).
RESULTS: In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; = 1.3 × 10) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; = 1.6 × 10) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.
CONCLUSIONS: This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.
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DOI | 10.1212/WNL.0000000000007001 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/30804065?dopt=Abstract |
page_expo | External |
Alternate Journal | Neurology |
PubMed ID | 30804065 |
PubMed Central ID | PMC6404465 |