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Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.

TitleHarmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
Publication TypeJournal Article
Year of Publication2019
AuthorsSmith EE, Biessels GJan, De Guio F, de Leeuw FErik, Duchesne S, Düring M, Frayne R, M Ikram A, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, M Gurol E, Ingrisch M, Job D, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, G Pike B, Ramirez J, Reijmer YD, Romero JRafael, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM
JournalAlzheimers Dement (Amst)
Date Published2019 Dec

Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.
Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.
Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.
Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

Pubmed Link
Alternate JournalAlzheimers Dement (Amst)
PubMed ID30859119
PubMed Central IDPMC6396326
Grant ListRF1 AG059421 / AG / NIA NIH HHS / United States
R01 AG049607 / AG / NIA NIH HHS / United States
R01 AG008122 / AG / NIA NIH HHS / United States
MR/J006971/1 / MRC_ / Medical Research Council / United Kingdom
R01 NS017950 / NS / NINDS NIH HHS / United States

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