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Design and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).

TitleDesign and Methodology of the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Publication TypeJournal Article
Year of Publication2020
AuthorsLee J, Khobragade PY, Banerjee J, Chien S, Angrisani M, Perianayagam A, Bloom DE, Dey AB
JournalJ Am Geriatr Soc
Volume68 Suppl 3
Date Published2020 08
KeywordsAged, Aging, Cognition, Dementia, Female, Geriatric Assessment, Humans, India, Interviews as Topic, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Research Design, Risk Factors

BACKGROUND/OBJECTIVES: To provide high-quality data on older adults in India that will enable an in-depth study of late-life cognition and dementia in India and cross-country analysis of risk factors for cognitive aging and dementia.
DESIGN: The Longitudinal Aging Study in India (LASI) is a nationally representative survey of health, economic, and social well-being of the Indian population aged 45 and older. Its large sample of more than 70,000 older adults represents not only the country as a whole but also each state. LASI-Diagnostic Assessment of Dementia (DAD) is an in-depth study of late-life cognition and dementia, drawing a subsample of over 3,000 LASI respondents aged 60 and older.
SETTING: Participants were interviewed at home or in a participating hospital according to their preferences.
PARTICIPANTS: Adults aged 60 and older (N = 3,224), along with 3,191 informants.
MEASUREMENTS: Respondents underwent a battery of cognitive tests, and informants were interviewed about their cognitive and health conditions. A common set of cognitive tests was selected to enable international comparisons, and additional cognitive tests suitable for illiterate and innumerate populations were also selected. Rich data on risk factors of dementia were collected through health examination, venous blood assays, and genotyping.
RESULTS: The response rate was 82.9%, varying across sex, education, and urbanicity. Data are available to other researchers.
CONCLUSION: LASI-DAD provides an opportunity to study late-life cognition and dementia and their risk factors in the older population in India and to gain further insights through cross-country analysis by pooling data from its international sister studies. J Am Geriatr Soc 68:S5-S10, 2020.

Pubmed Link
Alternate JournalJ Am Geriatr Soc
PubMed ID32815602
PubMed Central IDPMC7503220
Grant ListU01 AG064948 / AG / NIA NIH HHS / United States
R01 AG051125 / AG / NIA NIH HHS / United States
RF1 AG055273 / AG / NIA NIH HHS / United States

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