Data Notice- Review and Proposed Actions for False-Positive Association Results in ADSP Case-Control Data

Review and Proposed Actions for False-Positive Association Results in ADSP Case-Control Data

Some SNVs in the publicly released whole exome sequence (WES) QCed “consensus-called” data (which systematically integrated genotype calls from two pipelines: Atlas at Baylor College of Medicine and GATK at the Broad Institute) may have biased genotype calls resulting from sequence data generated/processed at the Broad Institute. This issue was identified by follow-up on likely “false-positive” genetic associations with genome-wide statistical significance in case-control analysis. It is not yet clear if this issue also affects WGS data.

Detailed information can be found here.