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Discovery Phase.

The ADSP Discovery Phase is comprised of five groups--two large, independent genetics consortia: the NIA-funded Alzheimer’s Disease Genetics Consortium (ADGC) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE); and three NHGRI-funded Large-Scale Genome Sequencing and Analysis Centers (LSACs): the Human Genome Sequencing Center at the Baylor College of Medicine (BCM-HGSC), the Broad Institute Genome Center, and the Genome Institute at Washington University.  Sample management is coordinated by National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)

ADSP Discovery Phase is supported by the National Institute on Aging (NIA) and the National Human Genome Research Institute (NHGRI).

Follow-Up Study Phase.

In the Follow-Up Study Phase, The American Genome Center (TAGC) of the Uniformed Services University of the Health Sciences (USUHS) provides in-kind sequencing for additional samples from ADGC, CHARGE and other cohorts, with emphasis on diversity/underrepresented minorities.  Sample and cohort management is coordinated by NCRAD and the FUS Project led by University of Miami.  Sequencing data are processed by the Genome Center for Alzheimer’s Disease (GCAD).  Data coordination and community sharing are managed by NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)

Sequencing and data deposition of the ADSP Follow-Up Phase are funded by the National Institute on Aging (NIA).


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