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Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.

TitleCardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.
Publication TypeJournal Article
Year of Publication2020
AuthorsPeloso GM, Beiser AS, Satizabal CL, Xanthakis V, Vasan RS, Pase MP, DeStefano AL, Seshadri S
JournalNeurology
Volume95
Issue10
Paginatione1341-e1350
Date Published2020 09 08
ISSN1526-632X
KeywordsAged, Cardiovascular Diseases, Comorbidity, Dementia, Female, Genetic Predisposition to Disease, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Risk Factors
Abstract

OBJECTIVE: To determine the joint role of ideal cardiovascular health (CVH) and genetic risk on risk of dementia.
METHODS: We categorized CVH on the basis of the American Heart Association Ideal CVH Index and genetic risk through a genetic risk score (GRS) of common genetic variants and the ε4 genotype in 1,211 Framingham Heart Study (FHS) offspring cohort participants. We used multivariable Cox proportional hazards regression models to examine the association between CVH, genetic risk, and incident all-cause dementia with up to 10 years of follow-up (mean 8.4 years, 96 incident dementia cases), adjusting for age, sex, and education.
RESULTS: We observed that a high GRS (>80th percentile) was associated with a 2.6-fold risk of dementia (95% confidence interval [CI] of hazard ratio [HR] 1.23-5.29; = 0.012) compared with having a low GRS (<20th percentile); carrying at least 1 ε4 allele was associated with a 2.3-fold risk of dementia compared with not carrying an ε4 allele (95% CI of HR 1.49-3.53; = 0.0002), and having a favorable CVH showed a 0.45-fold lower risk of dementia (95% CI of HR 0.20-1.01; = 0.0527) compared to having an unfavorable CVH when all 3 components were included in the model. We did not observe an interaction between CVH and GRS ( = 0.99) or ε4 ( = 0.16).
CONCLUSIONS: We observed that both genetic risk and CVH contribute additively to dementia risk.

DOI10.1212/WNL.0000000000010306
Pubmed Linkhttps://www.ncbi.nlm.nih.gov/pubmed/32690788?dopt=Abstract
page_expoExternal
Alternate JournalNeurology
PubMed ID32690788
PubMed Central IDPMC7538213
Grant ListR01 NS017950 / NS / NINDS NIH HHS / United States
R01 AG054076 / AG / NIA NIH HHS / United States
RF1 AG059421 / AG / NIA NIH HHS / United States
HHSN268201500001C / HL / NHLBI NIH HHS / United States
R01 AG049607 / AG / NIA NIH HHS / United States
N02 HL64278 / HL / NHLBI NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
HHSN268201500001I / HL / NHLBI NIH HHS / United States
U01 AG052409 / AG / NIA NIH HHS / United States
75N92019D00031 / HL / NHLBI NIH HHS / United States
U01 AG049505 / AG / NIA NIH HHS / United States
UH2 NS100605 / NS / NINDS NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States

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