Title | Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hänninen IK, Tanaka T, de Jonge EAL, de Jong JCKiefte-, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, M Ikram A, Jacques PF, Justice AE, Kiel DP, Lemaitre RN, Mendelson MM, Mikkilä V, Moore AZ, Pallister T, Raitakari OT, Schalkwijk CG, Sha J, Slagboom EPE, Smith CE, Stehouwer CDA, Tsai P-C, Uitterlinden AG, van der Kallen CJH, van Heemst D, Arnett DK, Bandinelli S, Bell JT, Heijmans BT, Lehtimäki T, Levy D, North KE, Sotoodehnia N, van Greevenbroek MMJ, van Meurs JBJ, Heil SG |
Journal | Am J Clin Nutr |
Volume | 110 |
Issue | 2 |
Pagination | 437-450 |
Date Published | 2019 Aug 01 |
ISSN | 1938-3207 |
Abstract | BACKGROUND: Folate and vitamin B-12 are essential micronutrients involved in the donation of methyl groups in cellular metabolism. However, associations between intake of these nutrients and genome-wide DNA methylation levels have not been studied comprehensively in humans. |
DOI | 10.1093/ajcn/nqz031 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/31165884?dopt=Abstract |
page_expo | External |
Alternate Journal | Am. J. Clin. Nutr. |
PubMed ID | 31165884 |
PubMed Central ID | PMC6669135 |
Grant List | K99 HL130580 / HL / NHLBI NIH HHS / United States R00 HL130580 / HL / NHLBI NIH HHS / United States R00 HL130580 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States K99 HL130580 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States |
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