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Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).

TitleAssociation Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).
Publication TypeJournal Article
Year of Publication2020
AuthorsSmith JA, Zhao W, Yu M, Rumfelt KE, Moorjani P, Ganna A, Dey AB, Lee J, Kardia SLR
JournalJ Am Geriatr Soc
Volume68 Suppl 3
PaginationS45-S53
Date Published2020 08
ISSN1532-5415
KeywordsAged, Aging, Alleles, Asians, Cognition, Dementia, Female, Genome-Wide Association Study, Genotyping Techniques, Humans, India, Male, Memory, Episodic, Neuropsychological Tests, Polymorphism, Single Nucleotide, Whites
Abstract

BACKGROUND/OBJECTIVES: Genetic factors play an important role in Alzheimer's disease (AD) and cognitive aging. However, it is unclear whether risk loci identified in European ancestry (EA) populations have similar effects in other groups, such as South Asians.
DESIGN: We investigated the allelic distribution and cognitive associations of 56 known AD risk single-nucleotide polymorphisms (SNPs) identified from three EA genome-wide association studies (EA-GWASs) in a South Asian population. Single SNP and genetic risk score (GRS) associations with measures of episodic memory were assessed.
SETTING: The Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD).
PARTICIPANTS: A total of 906 LASI-DAD participants from diverse states in India.
MEASUREMENTS: Participants were genotyped using the Illumina Global Screening Array and imputed with 1000G Phase 3v5. Cognitive measures included total learning and delayed word recall.
RESULTS: Although only a few SNPs were significantly associated with memory scores (P < .05), effect estimates from the EA-GWAS and the LASI-DAD showed moderate correlation (0.35-0.88) in the expected direction. GRSs were also associated with memory scores, although percentage variation explained was small (0.1%-0.6%).
CONCLUSIONS: Discrepancies in allele frequencies and cognitive association results suggest that genetic factors found predominantly through EA-GWASs may play a limited role in South Asians. However, the extent of differences in the genetic architecture of AD and cognition in EA and South Asians remains uncertain. There is also a critical need to perform a more comprehensive assessment of the mutational spectrum of South Asia to identify novel genetic variants associated with AD and cognition in this population. J Am Geriatr Soc 68:S45-S53, 2020.

DOI10.1111/jgs.16735
Pubmed Linkhttps://www.ncbi.nlm.nih.gov/pubmed/32815605?dopt=Abstract
page_expoInternal
Alternate JournalJ Am Geriatr Soc
PubMed ID32815605
PubMed Central IDPMC7507858
Grant ListR01 AG051125 / AG / NIA NIH HHS / United States
RF1 AG055273 / AG / NIA NIH HHS / United States
U01 AG064948 / AG / NIA NIH HHS / United States

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